Lactic Acid-Chitosan Films’ Properties and Their in vivo Wound Healing Activity

نویسندگان

  • T. S. Moe
  • T. A. Khaing
چکیده

Chitosan is a derivative of chitin, a compound usually isolated from the shells of some crustaceans such as crab, lobster and shrimp. It has biocompatible, biodegradable, and antimicrobial properties. To use these properties of chitosan in biomedical fields, chitosan films (1%, 2%, 3% and 4%) were prepared by using l% lactic acid as solvent. The effects of chitosan films on tensile strength, elongation at break, degree of swelling, thickness, morphology, allergic and irritation reactions and antibacterial property were evaluated. Staphylococcus aureus and Escherichia coli were used as tested microorganisms. In vivo wound healing activities of chitosan films were investigated using mice model. As results, Chitosan films have similar appearance and good swelling properties and 4% chitosan film showed the better swelling activity and the greatest elongation ratio than the other chitosan films. They also showed their good activity of wound healing in mice model. Moreover, the results showed that the films did not produce any unwilling symptoms (allergy or irritation). In conclusion, it is evident that the chitosan film has the potentiality to use as wound healing biofilms in the biomedical fields. Keywords—Chitosan, wound healing, antibacterial activity.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Semi-IPN Films and Electrospun Nanofibers Based On Chitosan/PVA as an Antibacterial Wound Dressing

The antimicrobial activity of a wound dressing is a key factor for preventing and treating wound infection. The current study evaluated the physiochemical properties and antimicrobial activities of semi-IPNs (interpenetrating polymer networks) based on chitosan/polyvinyl alcohol (PVA) films and nanofibers as candidates for wound dressings and investigated the effects of morphologies (nanofibrou...

متن کامل

Semi-IPN Films and Electrospun Nanofibers Based On Chitosan/PVA as an Antibacterial Wound Dressing

The antimicrobial activity of a wound dressing is a key factor for preventing and treating wound infection. The current study evaluated the physiochemical properties and antimicrobial activities of semi-IPNs (interpenetrating polymer networks) based on chitosan/polyvinyl alcohol (PVA) films and nanofibers as candidates for wound dressings and investigated the effects of morphologies (nanofibrou...

متن کامل

Development and Evaluation of Chitosan Honey Hydrogel Sheets as Wound Dressing

Multiplication of antibiotic resistant bacteria complicates the wound healing process nowadays. It has been proved that our ancient medicine honey is a panacea for a lot of diseases and it plays a vital role in wound healing. Hydrogel sheets were developed from chitosan and chitosan-honey in this study to evaluate the required properties for effective wound dressings, such as, folding endurance...

متن کامل

Wound dressing application of chitosan based bioactive compounds

Generation of immense quantity of underutilized marine processing byproducts has long been recognized as wastes and greater efforts were given to use these materials in various applications. With a great number of researches on these byproducts, some biologically active compounds were identified and implicated to the useful compounds for human utilization. Chitosan and silver nanoparticle have ...

متن کامل

Evaluation of the Antimicrobial Effect of Chitosan/Polyvinyl Alcohol Electrospun Nanofibers Containing Mafenide Acetate

BACKGROUND Chitosan, an important biodegradable and biocompatible polymer, has demonstrated wound-healing and antimicrobial properties. OBJECTIVES This study aimed to evaluate the antimicrobial properties of mafenide acetate-loaded nanofibrous films, prepared by the electrospinning technique, using chitosan and polyvinyl alcohol (PVA). MATERIALS AND METHODS A 3(2) full factorial design was ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2014